Polyinosinic acid-polycytidylic acid
- Product Name
- Polyinosinic acid-polycytidylic acid
- CAS No.
- 24939-03-5
- Chemical Name
- Polyinosinic acid-polycytidylic acid
- Synonyms
- polyi:c;polyi-c;Poly-Na;poly(i+c);Poly I:Cr;nsc-120949;polycpolyi;poly(ri:rc);Polyinosinic;polyri:polyrc
- CBNumber
- CB3181814
- Molecular Formula
- C19H27N7O16P2
- Formula Weight
- 671.41
- MOL File
- 24939-03-5.mol
Polyinosinic acid-polycytidylic acid Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble to 3 mg/ml in water
- Stability:
- Hygroscopic
- InChIKey
- ACEVNMQDUCOKHT-WOQDZEJINA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r|
Safety
- WGK Germany
- 3
- RTECS
- TR0175000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H402Harmful to aquatic life
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4287
- Product name
- Poly(I:C)
- Packaging
- 10
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 4287
- Product name
- Poly(I:C)
- Packaging
- 50
- Price
- $410
- Updated
- 2021/12/16
- Product number
- P688075
- Product name
- Poly(I:C)(~90%)
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- P688075
- Product name
- Poly(I:C)(~90%)
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- B5551
- Product name
- Poly(I:C)
- Packaging
- 10mg
- Price
- $97
- Updated
- 2021/12/16
Polyinosinic acid-polycytidylic acid Chemical Properties,Usage,Production
Uses
Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.
Definition
ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Biological Activity
poly (i:c), a synthetic double-stranded rna (dsrna) analog, is an immunostimulant that acts as the most potent interferon (ifn) inducer. toll-like receptor- 3 (tlr3) agonist[1].mixtures that included the tlr7/8 agonists r848 or cl075, combined with the poly (i:c), yield 3-d mature dendritic cells [2].commonly used to stimulate immune system activation in vivo. also promotes maturation of hpsc-derived cardiomyocytes[3].[1]. li y g, siripanyaphinyo u, tumkosit u, et al. poly (i:c), an agonist of toll-like receptor-3, inhibits replication of the chikungunya virus in beas-2b cells. virology journal, 2012, 9(1): 114.[2]. spranger s, javorovic m, burdek m, et al. generation of th1-polarizing dendritic cells using the tlr7/8 agonist cl075. the journal of immunology, 2010, 185(1): 738-747.[3]. biermann m1, cai w2, lang d, et al. epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. stem cells, 2019, 37(7): 910-923.
Polyinosinic acid-polycytidylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Polyinosinic acid-polycytidylic acid Suppliers
View Lastest Price from Polyinosinic acid-polycytidylic acid manufacturers
- Product
- Polyinosinic-polycytidylic acid sodium salt (PIC) 24939-03-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥90.0%
- Supply Ability
- 10 tons
- Release date
- 2024-02-06
- Product
- Polyinosinic-polycytidylic acid sodium salt 24939-03-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99.5%
- Supply Ability
- 20tons
- Release date
- 2023-02-21
- Product
- Polyinosinic-polycytidylic acid sodium salt 24939-03-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99.5%
- Supply Ability
- 20tons
- Release date
- 2023-02-21